TRIANNI's transgenic platform leverages a novel approach to design made possible by advances in DNA synthesis and genomic modification technology making it a best-in-class therapeutic antibody discovery platform. TRIANNI’s lead technology, The Trianni Mouse™ enables efficient generation of fully-human monoclonal antibodies. Compared with the subclasses of human antibody isotypes, mice contain only one IgA class and the IgG subclasses are known as IgG 1, IgG 2a, IgG 2b and IgG 3. The protein sequences of antibodies produced in this way are partially. This therapeutic agent was developed from the mouse antibody ‘anti-Tac’ by using the human mature antibody EU as framework acceptor sequences (FR scaffolds). It targeted the CD25 (Interleukin-2 receptor alpha chain) and was approved for therapeutic use in 1997. They produce similar antibody isotypes with human, including IgA, IgD, IgE, IgG and IgM. The first humanized antibody obtained by this technique was Daclizumab. The human immune system was developed by transplanting human tissues such as hematopoietic stem cells (HSCs) or PBMCs. This resulted in the mouses immune system producing antibodies against CD3. As expected, we observed that NOJ mice transplanted with human peripheral blood mono- nuclear cells (PBMCs) produced human anti-HA IgG antibodies after. Humanized mouse system with human immunity has been investigated extensively. Engrafted human cells can be detected as early as 10 days after the. In the case of muromonab, the antigen was the T-cell co-receptor CD3. We are now proud to announce our partnership with TRIANNI, a biotech company specializing in antibody discovery technology, TAKIS is now able to provide fully human monoclonal antibodies for its clients. For antibody discovery, mice are one of the most important sources. Once the immune system is knocked out, human PBMCs are injected to create a humanized model.

With the aim to offer best-in-class services to our worldwide customers, Takis has been looking for a transgenic animal platform that would allow the efficient generation of humanized antibody. We are now proud to announce our partnership with TRIANNI

Humanized mice antibody production